Table 3.

Comparison of retrospectively identified interstitial pneumonia with autoimmune features cohorts

	Oldham et al. (24)	Chartrand et al. (27)	Ahmad et al. (29)	Ito et al. (31)	Dai et al. (32)	Yoshimura et al. (34)	Kelly and Moua (35)
Patients, n	144	56	57	98	177	32	101
Age, yr, mean ± SD	63.2 ± 11	54.6 ± 10.3	64.4 ± 14	67.5 ± 9	67.6 ± 8.6	63.4 ± 12.6	56.9 ± 14.2
Female	52.1	71.4	49.1	58.2	55.9	40.6	39
Ever-smoker	54.9	32.1	34	38.8	19.2	56.2	31
Clinical	49.3	62.5	47.3	NR	20.3	53.1	NR
Serologic	91.7	91.1	93	100*	92.1	71.9	NR
Morphologic	85.4	98.2	78.9	100†	95.5	96.9	NR
Clinical and serologic	14.6	2	NR	NR	NR	3.1	4
Clinical and morphologic	8.3	9	NR	NR	NR	28.1	14
Serologic and morphologic	50.7	37.5	NR	100	NR	46.9	26
All three domains	26.4	52	NR	NR	NR	21.9	56
UIP by HRCT	54.6	8.9	28	0	4.5	NR	NR
Underwent SLB, n (%)	83 (57.6)	36 (64.3)	16 (28.1)	17 (17.3)	0‡	22 (68.8)	51 (50.5)
UIP on SLB, n (%)	61 (73.5)	8 (22.2)	3 (18.8)	3 (17.6)	—	—	12 (23.5)
Treatment
Corticosteroids	32.2	81.8	67.9	17.3	72.3	59.4	NR
Antifibrotic	NR	NR	5.4	2	NR	25	NR
Outcome
Death	39.6	0	12.3	27.6	19.8	NR	28
Lung transplant	10.8	NR	NR	NR	NR	NR	NR

Definition of abbreviations: HRCT = high-resolution computed tomography; NR = not reported; NSIP = nonspecific interstitial pneumonia; OP = organizing pneumonia; SD = standard deviation; SLB = surgical lung biopsy; UIP = usual interstitial pneumonia pattern.

Data presented as percentage unless otherwise stated.

^*Based on study design, inclusion criterion was positive serological evaluation.

^†Based on reported HRCT findings of NSIP, OP, or NSIP + OP in 98 of 98 subjects.

^‡All histopathology from transbronchial biopsies.