Table 4.

Impact of pretransplant DSA on additional post-transplant outcomes

Outcome		95% CI
Mechanical ventilation >5 d*	OR, 7.2	2.3–21.5
Freedom from any ACR†	HR, 0.5	0.2–1.1
Freedom from ACR grade 2 or higher†	HR, 0.6	0.2–1.9
De novo DSA‡	OR, 0.8	0.1–7.7
AMR requiring treatment§	OR, 7.5	1.0–55.8

Definition of abbreviations: ACR = acute cellular rejection; AMR = antibody-mediated rejection; CI = confidence interval; DSA = donor-specific antibodies; HR = hazard ratio; OR = odds ratio.

^*Adjusted for pretransplant mechanical ventilation, age, ethnicity, sex, native lung disease, ischemic time, and bilateral transplant status.

^†Out of 195 recipients who underwent biopsy; adjusted for age, native lung disease, bilateral transplant, and cytomegalovirus mismatch status.

^‡Out of 130 recipients screened for DSA; adjusted for sex, age, and ethnicity.

^§Out of 130 recipients screened for DSA and assessed for AMR; adjusted for sex, age, and the presence of pretransplant non-DSA HLA antibodies.