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. Author manuscript; available in PMC: 2019 Nov 12.
Published in final edited form as: Curr Biol. 2018 Nov 5;28(21):R1266–R1281. doi: 10.1016/j.cub.2018.08.034

Figure 1. Architecture and composition of SMC complexes.

Figure 1

(A) Ring-like architecture created by the association of the SMC and kleisin subunits and subunit composition of common prokaryotic (top two) and eukaryotic (bottom three; S. cerevisiae protein names) SMC complexes. *Note that Pds5 associates with the other cohesin subunits transiently and might hence not be a stoichiometric subunit of cohesin complexes. (B) Structure models of a κ-SMC ATPase head domain bound to the WHD located at the C terminus of the kleisin subunit (pdb: 1w1w; S. cerevisiae cohesin Smc1–Scc1) and of a ν-SMC ATPase head domain bound to the helical domain located at the N terminus of the kleisin subunit (pdb: 4ux3; S. cerevisiae cohesin Smc3–Scc1).