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. Author manuscript; available in PMC: 2019 Nov 12.
Published in final edited form as: Curr Biol. 2018 Nov 5;28(21):R1266–R1281. doi: 10.1016/j.cub.2018.08.034

Figure 5. Different models of active SMC-driven Loop Extrusion mechanism.

Figure 5

(A) Sequential walking model. (B) DNA pumping model. (C) Extended scrunching model. See main text for details. Note that the sequential walking model makes no assumptions about the SMC coiled coil conformations, whereas the pumping model assumes stiff coiled coils that are under tension when bent open. The extended scrunching models postulates that SMC coiled coils alternate between stiff and relaxed states.