Figure 7.

Schematic representation of the proposed mechanism of TOE on DSS‐induced colitis. DSS destroyed the integrity of mucosal barrier in mice and induced colonic inflammation. But TOE attenuated the clinical symptoms, lowered the inflammatory scoring and inhibited the secretion of pro‐inflammatory factors (TNF‐α, IL‐1β and IL‐6) in DSS‐induced colitis. TOE also increased the expression levels of Adh5, Aldh3a2 and Acox3, but down‐regulated the expression of CCL20, CCR6 and CXCL1/5 in DSS‐induced colitis. In addition, TOE regulated microbial dysbiosis in DSS‐induced colitis