Figure 8.

Suppression of NK‐1R/Akt/NF‐κB signaling pathways inhibited SP‐induced GBC cell growth in vivo. A, Tumor size of nude mice was measured by vernier caliper at the end of the treatment time in all groups. B and C, Weight of tumor obtained from tumor‐bearing mice is shown. D, Weight changes of nude mice in five separate groups were measured for 21 days. E and F, The phosphorylation of Akt and nuclear p65 of tumors were determined by western blot. G, Real‐time RT‐PCR was performed to detect the mRNA levels of IL‐6, IL‐1β, TNF‐α and MMP9 in tumors