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. 2019 Aug 7;317(4):C857–C866. doi: 10.1152/ajpcell.00281.2019

Fig. 4.

Fig. 4.

Pranlukast-dependent volume-regulated anion channel (VRAC) inhibition induces a second inactivation time constant. A: whole cell currents from human embryonic kidney 293 (HEK293) cells exposed to hypotonic and hypotonic bath + 3 µM pranlukast were measured using a step protocol at +120 mV. B: quantification of inactivation time constants generated from exponential fit curves (P = 0.003; Hypo + 3 µM pranlukast τ1 vs. Hypo + 3 µM pranlukast τ2, one-way ANOVA and Kruskal-Wallis post hoc test; n ≥ 4).