Table 6.
Negative correlation between combined expression of cancer stem cell markers CD133, CD44 and CD166 and epigenetic readers
| Family/gene symbol | Putative epidrug/chemical probe | Z-score | P value |
| Methylated DNA binding | |||
| MBD3 | - | -3.601 | 0.0003174 |
| ZBTB38 (Kaiso family) | - | -2.557 | 0.01055 |
| Histone binders | |||
| Bromodomains | |||
| BRD7 | BI72733, BI-95643, TP-4723[97] | -4.906 | 9.301E-07 |
| Zinc finger, Plant Homeodomain (PHD)-type | |||
| ING1, ING5 | - | -2.544/-4.255 | < 0.05 |
| PHF20 | - | -3.094 | 0.001973 |
| PHF14 | - | -2.934 | 0.003344 |
| PHF5A | - | -2.521 | 0.01171 |
| DPF1 | - | -2.78 | 0.00543 |
| Tudor domain | |||
| TDRKH | - | -2.755 | 0.005875 |
| WD40 motif | |||
| EED | A-3953[98] | -4.307 | 1.652E-05 |
| Other cofactors of epigenetic complexes | |||
| DPY30 | - | -3.549 | 0.0003863 |
| WDR5 | OICR-94293 | -3.31 | 0.0009321 |
| TADA2A | -2.473 | 0.01341 | |
1Approved for the treatment of other diseases; 2Used in clinical trials for other diseases;
3
Not yet used in clinical trials.