Table 4.
A clinical record compatible with CN involvement was found in 33% (5/15) by retrospective review of routine neurological examinations.
| Pat. No. | CN involved | Clinical record of CNE | Disease type | M/F | Age at MS onset [years] | Disease duration at incidence of CNE [days] | MS severity score (MSSS) |
|---|---|---|---|---|---|---|---|
| 12 | III | No | RRMS | F | 20 | 327 | 2.44 |
| 14 | III | Yes | RRMS | M | 29 | 72 | 0.67 |
| 2 | V | No | RRMS | M | 42 | 1 | 9.88 |
| 7 | V | No | RRMS | F | 14 | 804 | 0.35 |
| 8 | V | No | RRMS -> SPMS | F | 19 | 8,469 | 7.38 |
| 11 | V | Yes | RRMS | F | 23 | 6,138 | 1.89 |
| 15 | V | No | RRMS | M | 15 | 3,970 | 4.94 |
| 3 | VI | No | RRMS | F | 14 | 3,276 | 0.21 |
| 6 | VI | No | CIS -> RRMS | F | 38 | 1 | 6.0 |
| 10 | VI | No | RRMS -> SPMS | M | 27 | 4,917 | 2.34 |
| 13 | VI | No | RRMS | F | 20 | 7,526 | 5.15 |
| 1 | VII/VIII | Yes | RRMS | M | 13 | 66 | 6.14 |
| 5 | VII/VIII | Yes | RRMS | F | 30 | 1,552 | 5.79 |
| 9 | VII/VIII | No | RRMS | M | 28 | 39 | 5.41 |
| 4 | X | Yes | RRMS | M | 24 | 2,388 | 9.33 |
Between the first and last MRI, 7% (1/15) changed from clinically isolated syndrome (CIS) to relapsing remitting MS (RRMS) and 13% (2/15) changed from RRMS to secondary progressive MS (SPMS); all other cases remained RRMS. The female/male ratio was 8/7. There were 27% (4/15) who had a juvenile disease onset before the age of 18. The median age of MS-onset was 23 (15–29). In 40% (6/15), CNE presented within the first year after disease onset, and 13% (2/15) had CNE on their initial MRI at disease start. Patients with CNE had a median MS severity score (MSSS) of 5.15 (1.89–6.14) (25–75% range). Patient No. 2 suffered from intravenous drug abuse; Patient No. 1 presented with a juvenile Marburg-type MS.