Table 1.

Factors that may affect outcome of transplant.

Relevant factors for therapeutic strategy	With an influence on…
Genetic disease, PID	Ability to reject a graft Cellular lineages to be corrected (myeloid engraftment needed?) Intensity of tolerable conditioning
Clinical condition (infections, organ damage)	Intensity of tolerable conditioning
Donor availability	HLA match rejection GvHD Graft-versus-marrow effect
Stem cell source (bone marrow, PBSCs, CB)	Quantity and quality of cellular (sub-)populations in the graft GvHD Graft-versus-marrow effect
Graft manipulation (in vitro or in-vivo) T-cell depletion)	GvHD Graft-versus-marrow effect