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. 2019 Nov 12;9:16616. doi: 10.1038/s41598-019-51877-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kinetics of replication of P0-H3N2 and MA-H3N2 viruses in IC and IS mice. Group of mice (n = 5) were intranasally infected with 1 × 10⁴ PFU/mouse. Virus titers in the nasal turbinates (A) and lungs (B) of 5 mice per group sacrificed on 3 and 6 dpi are expressed as log₁₀ TCID₅₀/mL of tissue. Horizontal bars represent mean titers and symbols represent titers from individual mice. The dashed horizontal line indicates the lower limit of detection.