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. 2019 Nov 12;9:16588. doi: 10.1038/s41598-019-53223-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kinases targeted by Sangivamycin and Toyocamycin. (A,B) KINOMEscan screening was used to identify the kinase specificity of Sangivamycin and Toyocamycin at a concentration of 500 nM. The top ten hits for each compound is listed in the tables in. (B) The four overlapping kinases are highlighted in bold. (C) Cell lysates of HPDE cells or indicated PDA cell lines were analyzed by Western blot for expression of the main kinases targeted by Sangivamycin and Toyocamycin (anti-Haspin, anti-YSK4, anti-DYRK1A, anti-DYRK2). Staining for β-actin served as control for equal loading. (D) Immunohistochemistry (IHC) analysis of human PDA samples using anti-DYRK2, anti-YSK4, anti-DYRK1A, and anti-Haspin antibodies. The bar represents 100 µm.