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. 2019 Nov 12;9:16588. doi: 10.1038/s41598-019-53223-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Increased Haspin activity and expression in PDA can be linked to overall survival probability. (A,B) Tissue microarrays (n = 58 PDA samples) were analyzed by IHC for Haspin or its phosphorylated target Histone H3 using anti-Haspin or anti-pT3-Histone H3 antibodies. (A) Shows representative tissues that express Haspin and pT3-Histone H3 (top row), only express Haspin at low level (middle row), or are double negative for both (bottom row). (B) Shows a quantification n = 58 samples. (C) Overall survival probability of patients either expressing Haspin at high levels (n = 74 samples) or low levels (n = 72 samples). Shown is a Kaplan Curve using TCGA data (GSG_83903; expression cutoff: 29.2540).