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. 2019 Nov 12;9:16566. doi: 10.1038/s41598-019-53070-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between IPRP retention time, HILIC retention time, and FGF2 binding response by microarray analysis at 1 µg/mL, represented by bubble size. A strong correlation between HILIC retention time and FGF2 binding is apparent, indicating that FGF2 is binding ligands that are more highly sulfated. No correlation between IPRP retention time and FGF2 binding is apparent.