Table 1.
Overview on investigated Francisella tularensis subsp. holarctica genomes from Germany.
| F. tularensis holarctica ID | Year of isolation | Federal state ID Germany | Host organism | Clinical manifestation of pneumonia (+ yes, – no) | Biovar | Clade | Final subclade1 |
|---|---|---|---|---|---|---|---|
| Fth-41 | 2007 | BB | Human | Unknown | I | B.4 | – |
| Fth-39 | 2007 | TH | Hare | Unknown | II | B.12 | B.34/nd |
| A-63/63 (FDC407) | 2008 | BB | Fox | – | II | B.12 | B.74 |
| A-317 (FDC409) | 2012 | BB | Raccoon dog | Unknown | II | B.12 | B.71 |
| A-271-1 (FDC408) | 2012 | BB | Beaver | Unknown | II | B.12 | B.75 |
| A-702 | 2015 | BB | Wild boar | Unknown | II | B.12 | B.71 |
| A-655 | 2015 | B | Human | – | II | B.12 | B.34/nd |
| A-660 | 2015 | BW | Human | + | I | B.6 | B.45/nd |
| A-571 | 2015 | MV | Hare | Unknown | II | B.12 | B.33/nd |
| A-663 | 2015 | MV | Human | Unknown | II | B.12 | B.33/nd |
| A-635 | 2015 | NI | Human | + | I | B.6 | B.7 |
| A-797 | 2016 | BW | Human | – | II | B.12 | B.34/nd |
| A-820 | 2016 | BY | Human | + | I | B.6 | B.45/nd |
| A-821 | 2016 | BY | Human | – | I | B.6 | B.45/nd |
| A-810-1 | 2016 | NI | Human | – | II | B.12 | B.34/36 |
| Fth-Must° | 2016DNA | RP | Mice | Unknown | II | B.12 | B.34/nd |
| A-988-1 | 2016 | RP | Hare-L (lung) | – | I | B.6 | B.45/51 |
| A-988-2 | 2016 | RP | Hare-M (spleen) | – | I | B.6 | B.45/51 |
| A-1050 | 2017 | BB | Human | Unknown | II | B.12 | B.New |
| A-936 | 2017 | BW | Human** | – | I | B.6 | B.49 |
| A-981 | 2017 | BW | Human** | + | I | B.6 | B.45/nd |
| A-922 | 2017 | BW | Human | – | I | B.6 | B.45/nd |
| A-1007 | 2017 | BY | Human | – | I | B.6 | B.46/63 |
| A-1005 | 2017 | RP | Human** | – | I | B.6 | B.45/nd |
| A-1022 | 2017 | RP | Human | + | I | B.6 | B.45/nd |
| A-1020 | 2017 | RP | Human | + | I | B.6 | B.45/51 |
| A-1049 | 2017 | SH | Human | Unknown | I | B.6 | B.45/52 |
| A-1341 | 2018 | BB | Human# | – | II | B.12 | B.71 |
| A-1158 | 2018 | BW | Human | + | I | B.6 | B.45/50 |
| A-1174 | 2018 | BW | Human** | + | I | B.6 | B.45/nd |
| A-1308 | 2018 | BY | Human | – | II | B.12 | B.34/36 |
| A-1338 | 2018 | BY | Hare | Unknown | II | B.12 | B.33/nd |
| A-1183 | 2018 | BY | Human** | – | I | B.6 | B.45/53 |
| A-1201 | 2018 | BY | Human | Unknown | I | B.6 | B.45/nd |
| A-1171 | 2018 | NW | Human** | – | I | B.6 | B.45/nd |
Shown are the ID of the Francisella, the year of isolation, the federal state ID in which samples from patients and animals were collected, the host organism, and known clinical manifestation of pneumonia in humans as well as the biovar, the clade, and the final assigned subclade of the respective strain. BB, Brandenburg; B, Berlin; BW, Baden-Württemberg; BY, Bavaria; MV, Mecklenburg-Western Pomerania; NI, Lower Saxony; NW, North Rhine-Westphalia; RP, Rhineland-Palatinate; SH, Schleswig-Holstein; TH, Thuringia.
According to Wittwer et al. (2018), “nd” means no assignment of a final subclade available, currently no published reports.
No bacterial isolate, genomic DNA only; for further details, please see Jacob et al. (2019).
Clinical manifestation of the disease is possibly associated to tick bit.
Clinical manifestation of the disease seems to be connected to contact with wild boar.