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. 2019 Nov 6;13:490. doi: 10.3389/fncel.2019.00490

Figure 2.

Figure 2

Early AZM administration improves locomotor recovery in SCI mice. Adult (4-month-old) female mice received a moderate-severe thoracic T9 contusion SCI (75-kdyn). AZM was first administered at 30-min or 3-h post-injury and then daily for 7 days (160 mg/kg/day). Functional recovery was assessed before injury and at 1, 3, 7, 14, 21, and 28 dpi. (A) Mice treated with AZM beginning 30-min post-injury displayed significantly improved locomotor recovery relative to vehicle (main effect of treatment vehicle vs. 30 min, p = 0.004) with significant improvement from 14 to 28 dpi (**,***p < 0.05 30 min vs. vehicle, Holms–Sidak’s post hoc). Mice first treated at 3 h post-injury had increased recovery relative to vehicle (p = 0.06 main effect of treatment vehicle vs. 3 h) with significant improvements at 28 dpi (##p < 0.05 vs. vehicle Holms–Sidak’s post hoc). (B) Mice treated at 30-min recovered significantly improved frequent plantar stepping frequency than vehicle controls (58% and 17% respectively, Chi-squared, p = 0.001). Similarly, mice treated at 3-h recovered significantly more frequent plantar stepping relative to vehicle (37% and 17%, respectively, Chi-squared, p = 0.04). n = 24–29, mean ± SEM. *p < 0.05.