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. 2019 Sep 30;294(45):17090–17104. doi: 10.1074/jbc.RA119.010320

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© 2019 Yanda et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 1. — VX-809 slows cyst growth in pkd1^−/− mouse kidney. A, representative images of normal pkd1^+/+ (no doxycycline) or pkd1^−/− mouse kidney treated with doxycycline (doxy) to induce cyst formation and additionally treated with either DMSO or VX-809. Scale bar is 2 mm. B, measurement of % cyst area = cyst/total kidney cross-sectional area (43). Legends = mice injected only with DMSO, no doxycycline (ND); mice injected with DMSO + VX-809 (ND + VX-809); mice injected with doxycycline (D); mice injected with doxycycline + VX809 (D + VX-809). *, p < 0.05; ****, p < 0.0001; ns, not significant.