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. 2019 Sep 30;294(45):17090–17104. doi: 10.1074/jbc.RA119.010320

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© 2019 Yanda et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 10. — A and C, lack of ENaC and Rab11 co-localization. Representative confocal images of normal pkd1^+/+ (no doxycycline) or pkd1^−/− mouse kidney treated with doxy to induce cyst formation and additionally treated with either DMSO or VX-809. A, figures depict sections stained for ENaC (red) or Rab11 (green) or the merged image (yellow) that denotes co-localization. Enlarged represents a portion of the merged panel enlarged at the arrow. Scale bar is 10 μm. C, summary of Pearson's correlation coefficient, R. Note: ENaC did not show significant co-localization with the endosomal marker in either control or VX-809–treated animals. B and D, lack of ENaC and Na⁺/K⁺-ATPase co-localization. B, figure depicts sections stained for ENaC (red) or Na⁺/K⁺-ATPase (green) or the merged image (yellow) that denotes co-localization. Scale bar is 10 μm. D, summary of Pearson's correlation coefficient, R. Note: ENaC did not show significant co-localization with the basolateral marker in either control or VX-809–treated animals. **, p < 0.01; ns, not significant.