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. 2019 Sep 30;294(45):17090–17104. doi: 10.1074/jbc.RA119.010320

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© 2019 Yanda et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 7. — A and C, NHE3 and Rab11 co-localization. Representative confocal images of normal pkd1^+/+ (no doxycycline) or pkd1^−/− mouse kidney treated with doxy to induce cyst formation and additionally treated with either DMSO or VX-809. A, figure depicts sections stained for NHE3 (red) or Rab11 (green) or the merged image (yellow) that denotes co-localization. Enlarged represents a portion of the merged panel enlarged at the arrow. Scale bar is 10 μm. C, summary of Pearson's correlation coefficient, R. Note: NHE3 co-localization with the endosomal marker Rab11 decreased by about 50% following VX-809 treatment in the cystic kidneys. B and D, lack of NHE3 and GM130 co-localization. B, figure depicts sections stained for NHE3 (red) or GM130 (green) or the merged image (yellow) that denotes co-localization. Enlarged represents a portion of the merged panel enlarged at the arrow. Scale bar is 10 μm. D, summary of Pearson's correlation coefficient, R. Note that NHE3 does not co-localize with the cis-Golgi marker GM130. ****, p < 0.0001; ns, not significant.