Figure 8.

Lack of NHE3 and Na⁺/K⁺-ATPase co-localization. Representative confocal images of normal pkd1^+/+ (no doxycycline) or pkd1^−/− mouse kidney treated with doxy to induce cyst formation and additionally treated with either DMSO or VX-809. A, figure depicts sections stained for NHE3 (red) or Na⁺/K⁺-ATPase (green) or the merged image (yellow) that denotes co-localization. B, summary of Pearson's correlation coefficient, R. Note that NHE3 does not co-localize with the Na⁺/K⁺-ATPase in either the presence or absence of VX-809. ***, p < 0.001; ns, not significant.