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. 2019 Sep 30;294(45):16567–16576. doi: 10.1074/jbc.REV119.006514

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© 2019 Steele et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 1. — A, total number of strains in the current microbial strain collection at TSRI is as follows: actinobacteria (62,328, 28.7%); fungi (92,225, 42.4%); other bacteria (14,465, 6.7%); and unidentified bacteria or fungi (48,334, 22.2%). B, total number of extracts and fractions in the current NPL at TSRI is as follows: fungal extracts (136,123 made from 12,060 strains, 57.1%); fungal fractions (24,980 made from 2,498 strains, 10.7%); actinobacterial extracts (42,612 made from 8,020 strains, 18.2%); and actinobacterial fractions (32,832 made from 3,025 strains, 14.0%). C, collection dates of strains by decade: 1940s (A, 6.1%; F, 4.6%); 1950s (A, 26.8%; F, 15.0%); 1960s (A, 35.9%; F, 10.4%); 1970s (A, 7.4%; F, 4.2%); 1980s (A, 5.1%; F, 2.4%); 1990s (A, 6.7%; F, 63.2%); 2000s (A, 0.3%; F, 0.2%); and 2010s (A, 11.8%; F, 0.002%), where A indicates actinobacteria; F indicates fungi. These statistics are based on 77% of the actinobacteria, 46% of fungi, 80% of other bacteria, and 12% of unidentified bacteria or fungi from the total collection, for which collection dates could be traced. D, location of collection of strains is as follows: Brazil (F, 2.2%); Canada (A, 0.9%; F, 1.6%); China (A, 49.9%; F, 7.5%); Comoros Island (A, 0.8%); Egypt (F, 1.4%); Fiji (A, 0.9%); French Guiana (F, 2.3%); Indonesia (A, 13.6%; F, 4.4%); Italy (A, 0.8%); Japan (A, 0.9%); Korea (A, 4.2%); Malaysia (F, 2.6%); New Caledonia (F, 2.1%); Singapore (F, 1.6%); South America (A, 7.2%; F, 1.7%); Togo (A, 2.0%); United States (A, 12.2%; F, 56.0%); Venezuela (F, 1.3%); and other countries (A from 58 countries, 6.7%; F from 89 countries, 15.2%). These statistics are based on 20% of the actinobacteria and 41% of fungi from the total collection, for which collection locations could be traced. E, taxonomic information for actinobacteria is as follows: Actinomadura, 4.9%; Actinoplanes, 6.4%; Microbispora, 2.6%; Micromonaspora, 9.7%; Micropolyspora, 1.4%; Nocardia, 6.7%; Rhodococcus, 0.9%; Streptomyces, 55.2%; Streptosporangium, 1.1%; and the 79 other genera, 11.1%. Taxonomic information for fungi is as follows: Acremonium, 1.3%; Candida, 5.5%; Chaetomium, 1.6%; Fusarium, 4.4%; Mortierella, 1.1%; Mucor, 3.1%; Penicillium, 9.9%; Rhisopus, 1.2%; Trichoderma, 1.2%; and the 2,665 other genera; 70.7%. These statistics are based on 20% of the actinobacteria and 66% of fungi from the total collection for which some forms of the taxonomic data could be traced.