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Other variants at αArg-350 increase ENaC activity. Normalized currents obtained in the same batches of oocytes expressing WT and mutant channels are shown in A (αR350G and WT), B (αR350Q and WT), and C (αR350L and WT). Normalized currents (measured at −100 mV) were obtained as described in Fig. 2 legend. Data were pooled from three batches of oocytes for each WT and mutant pair. Bars are mean ± S.D. The p values were from Student's t tests.
