Skip to main content
. 2019 Oct 7;294(45):16535–16548. doi: 10.1074/jbc.REV119.008166

Figure 3.

Figure 3.

Amino acid selectivity of tyrosyl-tRNA synthetase. A, l-Tyr captured in the TyrRS amino acid–binding pocket; amino group, carbonyl oxygen, and the side chain hydroxyl groups help in substrate selectivity (PDB entry 1J1U). B, d-Tyr modeled in the TyrRS amino acid–binding pocket. C, overlap of d- and l-Tyr, clearly depicting the mode of amino acid binding and also explaining the weak enantioselectivity of TyrRS.