Amino acid selectivity of tyrosyl-tRNA synthetase.
A, l-Tyr captured in the TyrRS amino acid–binding pocket; amino group, carbonyl oxygen, and the side chain hydroxyl groups help in substrate selectivity (PDB entry 1J1U). B, d-Tyr modeled in the TyrRS amino acid–binding pocket. C, overlap of d- and l-Tyr, clearly depicting the mode of amino acid binding and also explaining the weak enantioselectivity of TyrRS.