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. 2019 Oct 7;294(45):16535–16548. doi: 10.1074/jbc.REV119.008166

Figure 5.

Figure 5.

Chiral discrimination at the A-site of the ribosome. Shown is the structure of the ribosome showing the A-site in complex with the aa-tRNA analog and the P-site with peptidyl-tRNA (taken from PDB entry 1VY4). The U2506 nucleotide of the 23S rRNA acts as a chiral discriminatory residue by allowing l-aa-tRNA to optimally orient for peptide bond formation but not the d-aa-tRNA. A, complex (PDB entry 6N9E) with l-aa-tRNA analog (CC-puromycin; for the sake of clarity, the hydroxy methyl of methyltyrosine is removed) shown in magenta. B, complex (PDB entry 6N9F) of d-aa-tRNA (ACCA-d-Phe) shown in yellow.