Figure 3.

Ligand activity of alkanes and derivatives. Siglec5 reporter cells were stimulated with plate-coated lipids for 18 h. Induction of NFAT was analyzed by flow cytometry. A, saturated alkanes of different lengths. B, octadecane derivatives. Chemical structures are shown in Fig. S3A. C, linear or cyclic pentadecane. D, tetracosane and multimethylated tetracosane, squalane. Chemical structures are shown in Fig. S3B. Data are representative of at least three independent experiments and are presented as the mean ± S.D. (error bars).