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MA promotes cisplatin-induced acute kidney injury through inhibiting FTO-mediated m6A modification. Treatment with cisplatin reduced FTO expression and increased the m6A levels in kidneys, which leads to the up-regulation of p53. MA aggravated the renal damages in cisplatin-treated kidneys through p53-mediated apoptosis pathways (the Bax/Bcl-2 and Caspase3 pathways).
