FIG 1.

Cell proliferation-associated lncRNA TMPO-AS1 positivity correlates with poor prognosis of breast cancer patients. (A and B) Representative results of in situ hybridization (ISH) analysis for TMPO-AS1 in malignant (A) and benign (B) mammary tissues. Scale bars, 100 μm. (C and D) Kaplan-Meier plot analysis showing the relationship between TMPO-AS1 ISH signals in cancer tissues and overall (C) and distant disease-free (D) survival of breast cancer patients (blue, ISH negative, n = 91; red, ISH positive, n = 37). (E) Relapse-free survival curve, analyzed by the Kaplan-Meier Plotter platform (http://kmplot.com/analysis/). TMPO-AS1 expression data were retrieved from 161 breast cancer patients treated with tamoxifen. P values and hazard ratios (HR) are shown.