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. 2019 Nov 12;9:16614. doi: 10.1038/s41598-019-53075-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Schematic of ovarian tissue encapsulation in PEG-PD. (B) Ovarian tissue encapsulated in PEG-PD before implantation, (C) at time of sacrifice, and (D) after removal. (E) Schematic of ovarian tissue encapsulation in Dual PEG. (F) Ovarian tissue encapsulated in Dual PEG before implantation, (G) at time of sacrifice, and (H) after removal. Black arrow indicates ovarian tissue, dotted black arrow points to PEG-PD core, white arrow points to the non-degradable PEG-based shell of the Dual PEG, and white dotted circle in C and G indicates area of gel. Drawings used to depict the encapsulation process were created using Adobe Illustrator (23.0.3 2019).