Fig. 4.

Histological findings in SLC35A2-mMCD2 brain specimens. a NeuN immunoreactivity of the middle frontal cortex region from patient FCD-2 shows blurred grey–white matter border (dashed line) and excess of heterotopic neurons ( > 30/mm²); scale bar: 1 mm. b Increased oligodendrocyte density in the white matter (below the dashed line) in the fronto-pre-central brain tissue from patient FCD-4; scale bar: 500 µm. c H&E staining of the pre-motor cortex tissue in patient FCD-4 shows white matter pallor; scale bar: 250 µm