Table 1.
Patient | Specimen | Grade | Cellularity | Vessels | Mitotic activity | Necrosis | MYCN-FISH | MYCN-IHC | GFAP | EMA | H3K27me3 | Ki67 up to (%) |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Primary | II | Low | No MP | Low | No | Amp | ++ | +++ | Dot-like | Retained | 3 |
1 | Relapse 1 | III | Low and high | No MP | Brisk | No | Amp | ++ to +++ | + with PE | Dot-like | Retained | 20 |
1 | Relapse 2 | III | High | MP | Brisk | Present | Amp | +++ | + with PE | Dot-like | Retained | 30 |
1 | Relapse 3 | III | High | MP | Brisk | Present | Amp | +++ | + with PE | Dot-like | Retained | 20 |
1 | Relapse 4 | III | High | MP | Brisk | Present | Amp | +++ | + with PE | Dot-like | Retained | 30 |
2 | Primary | III | High | No MP | Moderate | No | Amp | +++ | +++ | Dot-like | Retained | 15 |
2 | Relapse 1 | III | High | MP | Moderate | No | Amp | +++ | +++ | Dot-like | Retained | 15 |
2 | Relapse 2 | III | Low and high | MP | Brisk | Present | Amp | ++ to +++ | ++ with PE | Dot-like | Retained | 25 |
2 | Relapse 3 | III | High | MP | Brisk | Present | Amp | +++ | + with PE | Dot-like | Retained | 25 |
5 | Primary | III | Low and high | MP | Brisk | No | Amp | ++ to +++ | ++ with PE | Dot-like | Retained | 30 |
10 | Primary | III | Low and high | MP | Brisk | Present | Amp | ++ to +++ | ++ | Dot-like | Retained | 60 |
12 | Primary | III | Low and high | MP | Brisk | No | ND | ++ to +++ | ++ with PE | Dot-like | Retained | 40 |
MP microvascular proliferation, PE perivascular enhancement
+ focal, ++ weak to moderate and widespread, +++ strong and widespread