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. 2019 Nov 12;9:16647. doi: 10.1038/s41598-019-53145-x

Figure 1.

Figure 1

After an 8-hour insulin (INS) pretreatment (100 µg/ml) Caco-2 cells (A) were exposed to 5-fluorouracil (FU) (1) 500 µM, (2) 100 µM; irinotecan (IRI) (1) 150 µM, (2) 50 µM; oxaliplatin (OXA) (1) 50 µM, (2) 15 µM; docetaxel (DOC) (1) 4000 nM, (2) 1000 nM; cyclophosphamide (CPA) (1) 15 µM, (2) 4 µM and SW480 cells (B) were treated with FU (1) 500 µM, (2) 250 µM; IRI (1) 200 µM, (2) 100 µM; OXA (1) 198 µM, (2) 96 µM; DOC (1) 4000 nM, (2) 100 nM; CPA (1) 12 µM, (2) 6 µM for 48 hours. The inhibitory effect was measured by MTT assay. The results are shown as mean ± SD from three individual experiments. Statistically significant variables were marked with *(p < 0.05).