Table 3.

Basic statistical analysis of the hematologic test after the therapy in five groups of mice differing in the treatment method and the result of comparison (non- parametric Kruskal-Wallis test).

Parameter	Group 1	Group 2	Group 3	Group 4	Group 5	P value
Leukocytes (×103/μL)
Me ± SD	5,85 ± 2,12	6,07 ± 1,15	4,96 ± 3,36	4,65 ± 3,24	14,95 ± 14,43	0.762
Med [Q1; Q3]	5,3 [4,6; 7,2]	6,1 [4,9; 7,2]	5,5 [3,2; 7,2]	4,3 [2,9; 8,0]	10,1 [4,7; 25,2]
Min–Max	4,0–8,9	4,9–7,2	0,2–8,7	0,1–8,4	4,4–35,3
Lymphocytes (×103/μL)
Me ± SD	5,03 ± 1,85	5,17 ± 1,17	5,45 ± 2,22	4,84 ± 2,11	14,45 ± 14,07	0.804
Med [Q1; Q3]	4,7 [3,9; 6,2]	5,4 [3,9; 6,2]	5,7 [3,7; 7,3]	5,0 [2,8; 6,7]	9,6 [4,6; 24,4]
Min–Max	3,2–7,6	3,9–6,2	2,8–7,7	2,6–7,1	4,3–34,4
Monocytes (×103/μL)
Me ± SD	0,25 ± 0,10	0,30 ± 0,00	0,20 ± 0,12	0,20 ± 0,19	0,18 ± 0,15	0.763
Med [Q1; Q3]	0,2 [0,2; 0,3]	0,3 [0,3; 0,3]	0,2 [0,1; 0,3]	0,1 [0,1; 0,4]	0,2 [0,1; 0,3]
Min–Max	0,2–0,4	0,3–0,3	0,1–0,3	0,0–0,4	0,0–0,3
Granulocytes (×103/μL)
Me ± SD	0,58 ± 0,29	0,67 ± 0,15	0,45 ± 0,17	0,54 ± 0,34	0,33 ± 0,26	0.521
Med [Q1; Q3]	0,5 [0,4; 0,8]	0,7 [0,5; 0,8]	0,5 [0,3; 0,6]	0,4 [0,3; 0,9]	0,3 [0,1; 0,6]
Min–Max	0,4–1,0	0,5–0,8	0,3–0,6	0,2–0,9	0,1–0,6
Lymphocytes (%)
Me ± SD	85,4 ± 3,4	84,4 ± 5,0	88,6 ± 5,0	88,2 ± 3,7	96,4 ± 1,2	0.025
Med [Q1; Q3]	86 [83; 88]	87 [79; 88]	89 [86; 92]	90 [85; 91]	97 [96; 97]
Min–Max	81–89	79–88	82–95	84–92	95–97
Monocytes (%)
Me ± SD	4,7 ± 0,7	4,6 ± 0,5	3,7 ± 1,9	2,9 ± 1,5	1,2 ± 0,4	0.039
Med [Q1; Q3]	5 [4; 5]	4 [4; 5]	3 [2; 5]	2 [2; 4]	1 [1; 1]
Min–Max	4–6	4–5	2–6	1–5	1–2
Granulocytes (%)
Me ± SD	9,9 ± 2,8	11,0 ± 4,5	7,7 ± 3,1	9,0 ± 2,4	2,4 ± 0,8	0.063
Med [Q1; Q3]	9 [8; 12]	9 [8; 16]	8 [6; 10]	9 [7; 11]	2 [2; 3]
Min–Max	7–14	8–16	4–12	6–12	2–4
Erythrocytes (×106/μL)
Me ± SD	6,55 ± 2,26	7,42 ± 0,91	5,11 ± 2,69	5,61 ± 2,96	6,23 ± 0,90	0.497
Med [Q1; Q3]	7,0 [5,1; 8,0]	7,0 [6,8; 8,5]	5,9 [5,9; 6,0]	6,2 [5,1; 7,8]	6,1 [5,5; 7,0]
Min–Max	3,4–8,8	6,8–8,5	0,4–7,3	0,1–8,3	5,3–7,3
Hemoglobin (g/dL)
Me ± SD	10,7 ± 2,9	11,2 ± 0,3	7,8 ± 4,2	8,9 ± 4,6	10,1 ± 1,2	0.427
Med [Q1; Q3]	11 [9; 13]	11 [11; 11]	9 [9; 10]	10 [9; 12]	10 [9; 11]
Min–Max	7–14	11–11	0–11	0–13	9–12
Hematocrit (%)
Me ± SD	28,3 ± 8,7	31,2 ± 3,6	21,9 ± 11,4	28,7 ± 4,8	27,8 ± 3,2	0.428
Med [Q1; Q3]	30 [23; 34]	29 [29; 35]	25 [25; 27]	26 [26; 32]	28 [26; 30]
Min–Max	16–37	29–35	2–31	24–35	23–31
MCV (fL)
Me ± SD	43,8 ± 2,5	42,1 ± 0,4	43,3 ± 2,3	43,0 ± 2,3	45,1 ± 6,0	0.804
Med [Q1; Q3]	43 [42; 45]	42 [42; 43]	43 [42; 45]	42 [42; 43]	42 [42; 48]
Min–Max	42–48	42–43	41–46	41–47	42–54
MCH (pg)
Me ± SD	16,8 ± 1,8	15,2 ± 1,6	14,2 ± 2,7	16,0 ± 0,7	16,3 ± 1,4	0.335
Med [Q1; Q3]	16 [16; 18]	16 [13; 16]	15 [15; 15]	16 [16; 16]	16 [15; 17]
Min–Max	16–20	13–16	10–17	16–17	15–18
MCHC (g/dL)
Me ± SD	38,3 ± 1,9	36,1 ± 3,6	32,9 ± 6,6	37,3 ± 0,7	36,2 ± 1,6	0.129
Med [Q1; Q3]	38 [37; 40]	37 [32; 39]	35 [35; 36]	37 [37; 38]	37 [35; 37]
Min–Max	37–41	32–39	21–37	37–38	34–37
RDW (%)
Me ± SD	19,9 ± 1,0	19,6 ± 0,2	20,8 ± 1,9	21,0 ± 2,0	23,6 ± 8,7	0.618
Med [Q1; Q3]	20 [19; 21]	20 [20; 20]	21 [20; 21]	20 [20; 20]	19 [19; 28]
Min–Max	19–21	20–20	19–24	20–25	19–37
PLT (tys./μL)
Me ± SD	207 ± 53	305 ± 73	410 ± 201	490 ± 434	652 ± 281	0.072
Med [Q1; Q3]	223 [169; 245]	271 [255; 389]	453 [447; 511]	413 [264; 535]	563 [462; 843]
Min–Max	133–249	255–389	63–578	19–1296	429–1054
MPV (fL)
Me ± SD	6,7 ± 1,2	5,9 ± 0,2	6,2 ± 0,4	6,9 ± 1,1	6,1 ± 0,2	0.488
Med [Q1; Q3]	6 [6; 7]	6 [6; 6]	7 [6; 7]	7 [6; 8]	6 [6; 6]
Min–Max	6–9	6–6	6–7	6–8	6–6
PDW (fL)
Me ± SD	47,4 ± 7,4	47,8 ± 1,8	34,1 ± 7,9	31,0 ± 12,9	31,6 ± 10,5	0.080
Med [Q1; Q3]	50 [43; 52]	47 [46; 50]	37 [27; 41]	34 [23; 40]	36 [25; 38]
Min–Max	37–53	46–50	25–42	10–45	16–38
PCT (%)
Me ± SD	0,133 ± 0,016	0,179 ± 0,041	0,262 ± 0,133	0,311 ± 0,241	0,397 ± 0,169	0.073
Med [Q1; Q3]	0,14 [0,12; 0,15]	0,16 [0,15; 0,23]	0,29 [0,27; 0,34]	0,28 [0,18; 0,39]	0,33 [0,29; 0,51]
Min–Max	0,11–0,15	0,15–0,23	0,04–0,38	0,02–0,73	0,28–0,64

Me – mean; SD – standard deviation; Med – median; Q1 – lower quartile; Q3 – upper quartile; Min – minimal value; Max – maximal value, p – significance.