Table 1. Similarities and differences on defining acute on chronic liver failure in East (APASL), Europe (EASL), and USA (NACSELD).

Variable	APASL (1)	EASL (2)	NACSELD (3)
Underlying liver disease	Chronic liver disease and compensated cirrhosis	Compensated and decompensated cirrhosis	Decompensated cirrhosis
Common precipitating event/s	Alcoholic hepatitis; reactivation of hepatitis B	Alcoholic hepatitis; bacterial infection	Infection
Clinical criteria	Ascites and/or HE	Organ failure/s	Extrahepatic organ failure/s
Liver failure	Serum bilirubin ≥5 mg/dL	Serum bilirubin ≥12 mg/dL	Not described
Renal failure	AKI network criteria	Serum creatinine ≥2 mg/dL or renal replacement therapy	Renal replacement therapy
Coagulation failure	INR ≥1.5	INR ≥2.5	Not described
Brain failure	HE grade 3 or 4	HE grade 3 or 4	HE grade 3 or 4
Circulatory failure	Not described	Need for vasopressor/s	MAP <60 or decrease of systolic BP by 40 mmHg from baseline in spite of treatment
Respiratory failure	Not described	PaO2/FiO2 <200 or SpO2/FiO2 <214 or need of mechanical ventilation	Need for mechanical ventilation
Duration of event	4 weeks	4 weeks	30 days
Mortality	High	High	High