| Mancebo et al., 2013 (7) |
Prospective cohort |
Spain, 450 patients with ALD cirrhosis CTP A/B |
1992–2010 |
Annual incidence of HCC: 2.6% |
| Kodama et al., 2013 (26) |
Retrospective cohort |
Japan, 72 patients with NASH cirrhosis, 85 with ALD cirrhosis |
1990–2010 |
5-year HCC cumulative incidence: 12.3% in ALD cirrhosis |
| Dyson et al., 2014 (17) |
Retrospective cohort |
UK, 632 patients with HCC |
2000–2010 |
Proportion of ALDHCC: 28.2% by 2010 |
| Paranagua-Vezozzo et al., 2014 (27) |
Prospective cohort |
Brazil, 884 patients with compensated cirrhosis |
1998–2008 |
5-year accumulative incidence of HCC: 5.7% in ALD cirrhosis |
| Tateishi et al., 2015 (28) |
Retrospective cohort |
Japan, 33,782 patients with HCC, 53 hospitals, 5,326 (15.8%) were categorized as non-viral related HCC |
1991–2010 |
Proportion of ALDHCC: 26.7% |
| Younossi et al., 2015 (19) |
Retrospective cohort |
US, SEER registries, with 4,929 HCC cases |
2004–2009 |
Proportion of ALDHCC: 16.4% |
| Park et al., 2015 (3) |
Retrospective cohort |
BRIDGE, 14 countries, 42 sites, 8,031 HCC patients |
2005–2012 |
Proportion of ALDHCC: North America 21%, Europe 37%, China 5%, South Korea 9%, Japan 13% |
| Beste et al., 2015 (6) |
Retrospective cohort |
US, 129,998 cirrhosis, 21,326 HCC Veterans |
2001–2013 |
Incident ALDHCC increased from 3.92 to 6.16 per 100 000. |
| Akinyemiju, et al., 2017 (4) |
Meta-analysis |
195 countries or territories registration system data and cancer registry |
1990–2015 |
Proportion of HCC deaths due to alcohol use was 30% |
| Marot et al., 2017 (30) |
Retrospective cohort |
Belgium, 752 patients with cirrhosis |
1995–2014 |
Annual cumulative risks of ALDHCC: 1.1%; 10-year cumulative incidence rate of ALDHCC: 8.4% |
| Ganne-Carrie et al., 2018 (33) |
Prospectively cohort |
France and Belgium, 652 patients with compensated ALD cirrhosis |
2010–2016 |
Annual incidence of HCC: 2.9%, 1- and 2-year cumulative incidences of 1.8% and 5.2%, respectively |
| Younossi et al., 2019 (21) |
Retrospective cohort |
US, SRTR, 170,540 adult patients on the LT waitlist, 28,935 (17.0%) with HCC |
2002–2017 |
Proportion of ALDHCC increased from 8.3% to 14.2% |
