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. Author manuscript; available in PMC: 2020 Nov 13.
Published in final edited form as: Circulation. 2019 May 13;139(25):2892–2909. doi: 10.1161/CIRCULATIONAHA.118.036859

Figure 2.

Figure 2.

Role of big data in identifying novel genetic determinants of thyroid (dys)function. The identification of these markers is essential to perform reliable Mendelian randomization studies, which will clarify causality in the observed associations between thyroid (dys)function and cardiovascular complications. Furthermore, these genetic markers could play a role in Hypothalamus-Pituitary-Thyroid (HPT) axis setpoint prediction, which is essential to start personalizing the treatment of patients with thyroid diseases.