Table 1:
Clinical characteristics and MRI findings among a cohort of neonates with encephalopathy.
| Acute Seizures (n=15) | No Acute Seizures (n=11) | p-value | Epilepsy (n=4) | No Epilepsy (n=13) | p-value | |
|---|---|---|---|---|---|---|
| Male, n (%) | 10 (67) | 7 (63) | 0.87 | 2 (50) | 9 (69) | 0.48 |
| Average GA (wk)a | 39.4 (1.5) | 40.1 (1.2) | 0.21 | 39.9 (1.4) | 39.1 (1.2) | 0.33 |
| Birth Weight (g) a | 3337 (129) | 3175 (151) | 0.42 | 3375 (172) | 3289 (120) | 0.73 |
| Race, n (%) | ||||||
| American Indian | 1 (7) | 0 | 1 (25) | 0 | ||
| Asian/PI | 2 (13) | 3 (33) | 0.23 | 1 (25) | 3 (23) | 0.28 |
| Black | 4 (27) | 0 | 1 (25) | 3 (23) | ||
| White | 8 (53) | 6 (67) | 1 (25) | 7 (54) | ||
| Hispanic, n (%) | 0 | 2 | 0.09 | 0 | 0 | - |
| Encephalopathy | ||||||
| Etiology b | ||||||
| HIE/NE | 11 (73) | 11 (100) | 0.17 | 3 (75%) | 11 (84%) | 0.14 |
| Stroke | 3 (20) | 0 | 0 | 2 (16%) | ||
| Meningitis | 1 (7) | 0 | 1 (25%) | 0 | ||
| Encephalopathy Scorea (21, 22) | 5 (4–6) | 3 (2–4) | <0.001 | 6 (4–6) | 4 (4–6) | 0.13 |
| MRI Injury Score c (27) | 5 (2–9) | 2 (0–6) | 0.07 | 6 (5–8) | 3 (2–6) | 0.15 |
| Acute Seizures | Not applicable | 4 (100%) | 8 (62%) | 0.26 | ||
| Maternal Risk Factors | ||||||
| Age (years) a | 30.5 (8.4) | 30.7 (6.1) | 0.97 | 25.4 (6.4) | 30.8 (6.6) | 0.17 |
| Steroid treatment, n (%) | 1 (7) | 0 | 0.38 | 0 | 1 (8) | 0.57 |
| Antibiotic, n (%) | 5 (33) | 4 (36) | 0.87 | 3 (75) | 3 (23) | 0.06 |
| Fever, n (%) | 2 (13) | 3 (27) | 0.49 | 1 (25) | 1 (8) | 0.10 |
a
: mean (95% CI) or
b
median (interquartile range).
c
Radiologic evidence of HIE (including gray or white matter injury), radiologic evidence of ischemic or hemorrhagic stroke, and laboratory evidence of meningitis.
Abbreviations: GA: Gestational age; HIE/NE: Hypoxic-ischemic encephalopathy/ Neonatal encephalopathy; IQR: Interquartile Range; wk: week.