Skip to main content
. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Acta Biomater. 2019 Aug 22;99:72–83. doi: 10.1016/j.actbio.2019.08.032

Figure 8.

Figure 8.

Immunohistochemistry of brain tissue implanted with control and iSODm coated dummy probes. (A-C) Neuronal apoptosis. Neurons co-labeled with caspase-3 showed increased neuronal apoptosis near the implant (example cells indicated by white arrows), however, there was a significant reduction in apoptotic neurons near iSODm coated implant within 0-25 μm compared to control. (D-F) Oxidative stress (4HNE). Both implants showed elevated 4HNE expression immediately adjacent to the implant. However, iSODm coated electrodes significantly reduced overall 4HNE activity across all distance bins compared to control implants. n = 16 (control) n = 17 (iSODm) for each implant type; 2-3 repeated measures for each implant location (n = 7 locations for each implant type across N = 3 animals), *p<0.05. Error bars represent standard error of the mean. Scale bars represent 50 μm. Two-way ANOVA was used for comparisons in (C). Student’s t-test was used for comparisons in (F) in the first distance bin.