Table 3. Univariate and multivariate Cox analyses of EFS in osteosarcoma.

Variables	HR (95% CI)	P
Univariate analysis
CXCR3 (low vs. high)	2.45 (1.38–4.35)	0.002
Gender (male vs. female)	1.25 (0.70–2.21)	0.453
Age (≥15.1 vs. <15.1 years)	0.67 (0.38–1.17)	0.161
Metastasis (yes vs. no)	2.68 (1.50–4.80)	<0.001
Tumor site (femur vs. tibia)	2.53 (1.10–5.83)	0.029
Tumor region (distal vs. proximal)	2.64 (1.17–5.94)	0.019
Surgery (limb sparing vs. amputation)	0.89 (0.31–2.57)	0.827
Progression (yes vs. no)	3.41 (1.71–6.81)	<0.001
Histologic response (poor vs. good)	4.50 (1.55–13.08)	0.006
Multivariate analysis
CXCR3 (low vs. high)	4.45 (0.82–24.28)	0.085
Metastasis (yes vs. no)	1.74 (0.35–8.52)	0.497
Tumor site (Femur vs. Tibia)	5.86 (0.51–66.73)	0.154
Progression (yes vs. no)	2.97 (0.64–13.80)	0.164
Histologic response (poor vs. good)	1.05 (0.16–6.77)	0.963