Table 1. The expression profiles of lncRNAs in CVDs.
| Species | Models | Differentially expressed lncRNAs | Samples |
|---|---|---|---|
| Homo sapiens | Hypoxic condition | 164: 8 were up-regulated by more than 1.5-fold and 18 were down-regulated by more than 1.5-fold (GSE50378) | HUVEC cells [5] |
| 119: 35 up and 30 down were taken as representative (GSE22282) | Mature dendritic cells [5] | ||
| Mouse | MI/RI | 151: 64 up and 87 down (fold-change > 2.0) | Infarct region of heart [17] |
| Mouse | MIPostC corresponding to MI/RI | 4140: 2292 up and 1848 down (absolute fold-change > 2.0) (vs. I/RI) | Heart tissues [18] |
| Mouse | The early stage of MI | 642: 301 up and 341 down (FDR < 0.05, |log2FC| > 1) | Left ventricular tissues [19] |
| Mouse | MI | 1173: 194 up and 979 down (FDR < 0.05, |log2FC| > 1) | Left ventricular tissues [19] |
| 133: 67 up and 66 down (UCSC-annotated) | Heart tissues [6] | ||
| 311: 86 up and 225 down (novel unannotated) | |||
| Human | ICM | 145: 108 up and 37 down | Myocardial samples [7] |
| Rat | AngiotensinII-induced autophagy | 1249: 700 up and 549 down (≥two-fold change) | Neonatal cardiomyocytes [8] |
| Mouse | Cardiac fibrosis induced by MI | 545: 263 up and 282 down (53 were up-regulated by 2.0-fold change and 37 down-regulated by 0.5-fold change) | Peri-infarct tissues of heart [9] |
| 198: 64 were up-regulated by | |||
| Mouse | CH (isoproterenol) | 2.0-fold change and 134 down-regulated by 0.5-fold change | Left ventricle tissues [10] |
| Rat | CH (TAC) | 252: 80 up and 172 down (fold-change > 2.0) | Heart tissues [11] |
| Human | DCM | 313: 139 up and 174 down (fold change > 2) | Heart tissues [12] |
| Rat | Ischemic HF (by ligating the LAD) | 2600: 1197 up and 1403 down (fold-change > 2.0) | Heart tissues [13] |
| Human | HF | 48: 13 up and 35 down (vs. unused RVs) | HF right ventricular (RV) tissues of patients [14] |
| 13: 10 up and 3 down (fold change ≥ |1|) | LV biopsies of patients [15] | ||
| 768: 550 up and 218 down (>two-fold change) | Plasma of patients [16] |
Abbreviations: AMI, acute myocardial infarction; CH, cardiac hypertrophy; DCM, dilated cardiomyopathy; FC, fold-change; FDR, false discovery rate; HF, heart failure; ICM, ischemic cardiomyopathy; IPostC, ischemic postconditioning; LAD, left anterior descending coronary artery; MI, myocardial infarction; MI/RI, myocardial ischemia–reperfusion injury; TAC, transaortic constriction.