Table 2. The roles of lncRNAs in MI.

LncRNA	Models	Expression	Role
ZFAS1	AMI patients	Down	[21]
	AMI in rats	Up	Knockdown of ZFAS1 could relieve AMI-induced MI [22]
	MI in mice	Up	Knockdown of ZFAS1 could mitigate the ischemic contractile dysfunction of hearts [23]
HOTAIR	AMI in mice	Down	Limiting cardiomyocyte apoptosis [24]
	H9c2 cells under H2O2 treatment	Down	HOTAIR could relieve oxidative stress-induced H9c2 cells injury [25]
CAIF	Neonatal mouse cardiomyocytes under H2O2 treatment	Down	Inhibiting cardiac autophagy and ameliorating MI [26]
MALAT1	MI in mice and H9c2 cells treated with isoproterenol (ISO)	Up	Enhancing protective autophagy and decreased apoptosis of hearts in mice after MI [28]
	MI in mice and human ventricular myocyte AC16 cells under hypoxia	Up	Knockdown of MALAT1 could improve cell viability and inhibit cell apoptosis in hypoxia-induced cardiomyocytes [29]
GAS5	H9c2 cells under H2O2 treatment	Up	Knockdown of GAS5 could attenuate cell apoptosis in hypoxia-induced cardiomyocytes [32]
FAF	AMI in rats and neonatal rat primary cardiomyocytes under ischemia–hypoxia	Down	FAF could inhibit cell apoptosis ischemia–hypoxia induced cardiomyocytes [33]
TTTY15	Human cardiomyocyte primary cells (HCMs) under hypoxia condition	Up	Knockdown of TTTY15 could reduce hypoxia-induced cardiomyocytes injury [34]
ECRAR	MI in rats	-	Increasing rat post-natal CM proliferation after MI and improving post-MI cardiac function in adult rats [35]
CPR	MI in mice	-	Ablation of CPR could increase cardiomyocyte proliferation and improve cardiac function in mice after MI [36]
NR_045363	MI in mice	-	Increasing cardiomyocyte proliferation and improving cardiac function in mice after MI [38]
TUG1	Rat cardiomyocytes under hypoxia treatment	Up	Aggravating hypoxia-induced cell injury [40]
Meg3	Rat cardiomyocyte-derived H9c2 cells under hypoxia	Up	Knockdown of MEG3 could alleviate hypoxia-induced cell injury [42]

Abbreviations: AMI, acute MI; CAIF, cardiac autophagy inhibitory factor; CPR, cardiomyocyte proliferation regulator; ECRAR, endogenous cardiac regeneration-associated regulator; FAF, fibroblast growth factor 9-associated factor; GAS5, growth arrest-specific transcript 5; HOTAIR, HOX transcript antisense intergenic RNA; MALAT1, metastasis-associated lung adenocarcinoma transcript 1; TTTY15, testis-specific transcript Y-linked 15; ZFAS1, Zinc finger antisense 1.