Table 4. The roles of lncRNAs in cardiac remodeling.
| LncRNA | Models | Expression | Role |
|---|---|---|---|
| MIAT | Rat cardiomyocytes hypertrophy induced by AngII | Up | Promoting AngII-induced CH in rats [63] |
| Mouse CH and NRVMs hypertrophy induced by ISO | Up | Enhancing ISO-induced cardiomyocytes hypertrophy [64] | |
| Chaer | CH in mice induced by TAC | Down | Inhibition of Chaer could alleviate CH induced by TAC [65] |
| Chast | CH in mice induced by TAC | Up | Chast silencing could attenuate TAC-induced pathological cardiac remodeling [66] |
| MAGI1-T1 | H9c2 cells under AngII treatment | Down | Attenuating AngII-induced cardiomyocyte hypertrophy [68] |
| CYTOR | CCH in rats induced by AB and AngII-induced cardiomyocyte hypertrophy in H9c2 cells | Up | Knockdown of CYTOR could aggravate cardiomyocyte hypertrophy in vitro and in vivo [69] |
| XIST | CH in mice induced by TAC and PE-treated rat cardiomyocytes | Up | Aggravating cardiomyocyte hypertrophy induced by PE [72] |
| SNHG7 | Neonatal rat cardiac myocytes (NRCMs) under AngII treatment | Up | Knockdown of SNHG7 could attenuate AngII-induced cardiomyocyte hypertrophy [73] |
| Mhrt | CH in mice induced by TAC | Down | Inhibiting CH and failure [76] |
| UCA1 | Mouse CH induced by TAC induced by neonatal cardiomyocytes PE | Up | Promoting the progression of CH [77] |
| H19 | Mouse CH induced by TAC and neonatal ventricular myocytes hypertrophy induced by PE | Up | Reducing cell size both at baseline and in stimulation of PE [46] |
| SRA1 | AAB-induced rat cardiac fibrosis and newborn rat primary cardiac myofibroblasts under AngII treatment | Up | Promoting activation in cardiac myofibroblasts under AngII treatment [79] |
| MIAT | MI in mice and neonatal mouse cardiac fibroblasts under fetal bovine serum or AngII treatment | Up | Knockdown of MIAT could abate cardiac fibrosis and enhance cardiac function [80] |
| Meg3 | Cardiac remodeling in mice induced by TAC | Up | Inhibition of Meg3 could decrease cardiac fibrosis and ameliorate diastolic dysfunction [81] |
Abbreviations: AAB, abdominal aortic banding; Chaer, CH-associated epigenetic regulator; Chast, CH-associated transcript.; PE, phenylephrine; SNHG7, Small nucleolar RNA host gene 7; TAC, transaortic constriction; XIST, X-inactive specific transcript.