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. 2019 Nov 12;39(11):BSR20190966. doi: 10.1042/BSR20190966

Table 5. The roles of lncRNAs in other myocardial pathologies.

LncRNA Models Expression Role
FOXC2-AS1 DOX-induced cardiotoxicity in mice Down Inhibiting DOX-induced cardiomyocyte death [83]
CHRF HF in mice under DOX treatment Up Promoting myocardial cell apoptosis [84]
Mhrt Rat cardiomyopathy under DOX treatment Down Improving cell apoptosis of primary cardiomyocytes [85]
MALAT1 IL-6 induced murine septic cardiomyocytes under LPS treatment Up Enhancing TNF-α expression in LPS-treated murine HL-1 cardiomyocytes [86]
NEAT1 Sepsis in mice under LPS treatment Up Knockdown of NEAT1 could attenuate myocardial injury induced by LPS in mice [88]
HOTAIR Sepsis in mice under LPS treatment Up Silencing of HOTAIR could preserve cardiac function in sepsis mice [89]
Crnde DCM in mice Up Crnde could ameliorate cardiac fibrosis in DCM mice [92]
MALAT1 DCM in rats Up MALAT1 knockdown could significantly reduce cardiomyocyte apoptosis and markedly improve left ventricular systolic and diastolic functions [93]
DCM in mice and mice cardiomyocytes under high glucose treatment Up MALAT1 knockdown could reduce mice cardiomyocyte apoptosis induced by high glucose [94]
H19 DCM in rats Down Inhibiting autophagy activation and improve cardiac function [95]