Table 2.
Change from baseline and between‐treatment comparisons for change in Schiff sensitivity score and tactile threshold (intent‐to‐treat population)
| Test | Control | Test versus controlc | |
|---|---|---|---|
| Schiff sensitivity scorea | |||
| Study 1 | |||
| Baseline | 2.82 (0.031) | 2.80 (0.031) | |
| Immediate |
−0.41 (−0.54, −0.27) p < .0001 |
−0.31 (−0.44, −0.18) p < .0001 |
−0.09 (−0.280, 0.092) p = .3226 |
| Day 3 |
−0.96 (−1.14, −0.78) p < .0001 |
−0.77 (−0.95, −0.59) p < .0001 |
−0.18 (−0.442, 0.072) p = .1575 |
| Study 2 | |||
| Baseline | 2.12 (0.028) | 2.12 (0.028) | |
| Immediate |
−0.89 (−0.97, −0.81) p < .0001 |
−0.17 (−0.25, −0.09) p < .0001 |
−0.72 (−0.839, −0.610) p < .0001 |
| Day 3 |
−1.40 (−1.49, −1.30) p < .0001 |
−0.38 (−0.48, 0.28) p < .0001 |
−1.02 (−1.150, −0.882) p < .0001 |
| Study 3 | |||
| Baseline | 2.18 (0.033) | 2.18 (0.033) | |
| Immediate |
−0.63 (−0.73, −0.54) p < .0001 |
−0.38 (−0.47, 0.28) p < .0001 |
−0.26 (−0.387, −0.123) p = .0002 |
| Day 3 |
−1.37 (−1.46, −1.28) p < .0001 |
−0.45 (−0.54, 0.35) p < .0001 |
−0.92 (−1.055, −0.793) p < .0001 |
| Tactile threshold (g)b | |||
| Study 1 | |||
| Baseline | 10 (10, 20) | 10 (10, 20) | |
| Immediate | 0 (−5, 65)d | 0 (−10, 40)d | p = .3372 |
| Day 3 | 10 (−10, 80)d | 5 (−10, 80)d | p = .3719 |
| Study 2 | |||
| Baseline | 10.85 (0.229) | 10.69 (0.193) | |
| Immediate |
19.42 (17.16, 21.68) p < .0001 |
3.74 (1.47, 6.01) p = .0014 |
15.68 (12.476, 18.883) p < .0001 |
| Day 3 |
35.48 (32.40, 38.55) p < .0001 |
6.55 (3.47, 9.62) p < .0001 |
28.93 (24.576, 33.277) p < .0001 |
| Study 3 | |||
| Baseline | 12.35 (0.373) | 11.76 (0.346) | |
| Immediate |
15.19 (12.81, 17.56) p < .0001 |
8.05 (5.67, 10.43) p < .0001 |
7.14 (3.768, 10.506) p < .0001 |
| Day 3 |
32.87 (30.03, 35.71) p < .0001 |
10.37 (7.50, 13.24) p < .0001 |
22.50 (18.458, 26.541) p < .0001 |
Baseline values are raw mean scores (± standard error); post‐baseline values are adjusted mean changes from baseline (± 95% confidence interval).
Baseline values are raw median scores (minimum, maximum) for Study 1, raw mean scores (± standard error) for Studies 2 and 3; post‐baseline values are adjusted median change from baseline scores (minimum, maximum) for Study 1, adjusted mean change from baseline scores (± 95% confidence interval) for Studies 2 and 3.
Difference (95% confidence) p‐value from ANCOVA model: first‐named minus second‐named group. For Schiff sensitivity score, a negative difference favours the first‐named group. For Study 1 tactile threshold, p‐value is from a van Elteren nonparametric test. For tactile threshold (Studies 2 and 3 only), a positive difference favours the first‐named group.
The analysis of the statistical significance of change from baseline in Tactile threshold was not performed for Study 1.