Figure 2.

Resident memory T cells in vitiligo. The role of resident memory T cells in human vitiligo is shown. Firstly, Cheuk et al. (2017) reported an increase in CD49a⁺ T_RM cells in vitiligo skin, which produce IFN‐γ, granzyme B, and perforin upon IL‐15 stimulation. Furthermore, a substantial proportion of CD49a⁺ T_RM cells recognized melanocyte antigens, indicating a pathogenic role. Secondly, Boniface et al. (2018) showed vitiligo perilesional skin to be enriched with melanocyte‐specific CXCR3⁺CD8⁺ T_RM cells and CD8⁺ T_RM cells were poised for secretion of IFN‐γ and TNF‐α with moderate cytotoxic activity