Figure 3.

Therapeutic intervention in vitiligo. Potential therapeutic approaches for vitiligo are illustrated. Two murine studies showed that targeting T_RM cells can reverse disease in mice with established vitiligo. The left model shows T_RM cells express the IL‐15 receptor subunit CD122 and treatment with anti‐CD122 antibody led to repigmentation. Short‐term treatment led to less IFN‐γ production by T_RM cells, and long‐term treatment depleted autoreactive T_RM cells and other memory T‐cell pools. The right model shows that T_RM and T_CM cells cooperate to maintain vitiligo. Treatment of mice with FTY720, which limits T‐cell access to the skin, or low‐dose Thy1.1 antibody, which depletes T_CM, resulted in repigmentation