Figure 4.

Resident memory T cells in melanoma. Skin‐resident memory T cells can have various roles in melanoma; (1) T_RM cells can mediate anti‐tumor immunity, upon vitiligo induction strategies or intradermal vaccine administration (murine data), (2) CD8⁺ T_RM cells promote a melanoma–immune equilibrium in the epidermis (murine transplanted melanoma model), (3) tumor infiltration of T cells expressing either CD103 or CD49a, frequently co‐expressed with CD69 and CD103, is correlated with improved survival of melanoma patients, and (4) metastatic melanoma patients show expression of the immune checkpoints PD‐1, LAG‐3, 2B4, and TIM‐3 on intratumoral T_RM cells, with or without CD103 co‐expression