Statistical comparison of end points between the two C1‐INH doses

Efficacy end‐points	t test		Mixed‐effects model
	Mean difference	P valuea	Adjusted mean difference	P valueb
Number of angioedema attacks	−0.40	0.035	−0.43	0.030
Cumulative attack severity	−0.66	0.055	−0.71	0.043
Cumulative daily severity	−1.85	0.045	−1.71	0.066
Number of treated acute attacks	−0.22	0.067	−0.23	0.068

C1‐INH, C1 inhibitor.

^a P value and 90% confidence intervals are based on 2‐sided paired t test at α = 0.1.

^b P values, 90% confidence intervals, and adjusted means are based on mixed‐effects model at α = 0.1, with period, treatment, and sequence as fixed effects and subject nested within sequence as random effect.