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. 2019 Aug 23;112(4):1284–1307. doi: 10.1111/mmi.14362

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© 2019 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Part of the central carbon metabolism network (CCM) in Mtb. Scheme depicting enzymes and metabolites of some CCM pathways. Gluconeogenesis and glycolysis in green; Krebs cycle in brown; glyoxylate shunt in violet; methylcitrate pathway in orange; GABA shunt in light blue; anaplerotic (Mez) and cataplerotic reactions (Mez and Pca) in grey. The directionality of pathways is indicated on the base of current scientific knowledge of bacteria grown in aerobic conditions. The enzymes are described in agreement with https://mycobrowser.epfl.ch/ or otherwise indicated. AceE (Rv2241): pyruvate dehydrogenase E1 component; AceAa/b (Rv1915/Rv1916): isocitrate lyase; Acn (Rv1475c): aconitase; DlaT (Rv2215): dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase; Eno (Rv1023): enolase; Fba (Rv0363c): fructose‐biphosphate aldolase; FrdABCD (Rv1552‐Rv1555): fumarate reductase; Fum (Rv1098c): fumarase; GabD1/2 (Rv0324c/Rv1731): succinate‐semialdehyde dehydrogenase; GabT (Rv2589): 4‐aminobutyrate aminotransferase; GadB (Rv3432c): glutamate decarboxylase; Gap (Rv1436): glyceraldehyde 3‐phosphate dehydrogenase; Gdh (Rv2476c): glutamate dehydrogenase; GlcB (Rv1837c): malate synthase; GlkA (Rv0650): glucokinase; GlpX (Rv1099c): fructose 1,6‐biphosphatase; GltA2 (Rv0896): citrate synthase; Gpm1 (Rv0489): phosphoglycerate mutase; Gpm2 (Rv3214): fructose 1,6‐biphosphatase; KorA/B (Rv2454c/Rv2455c)^**: anaerobic α‐ketoglutarate dehydrogenase; HOAS (Rv1248c)^***: 2‐hydroxy‐3‐oxoadipate synthase; Icd1/2 (Rv3339c/Rv0066c): isocitrate dehydrogenase; Icl1 (Rv0467): Isocitrate lyase; LldD2 (Rv1872c): lactate dehydrogenase; Lpdc (Rv0462): dihydrolipoamide dehydrogenase; Mez (Rv2332): malic enzyme; Mdh (Rv1240): malate dehydrogenase; Pca (Rv2967c): pyruvate carboxylase; PckA (Rv0211): phosphofructokinase; PfkA (Rv3010C): phospho‐fructokinase; Pgi (Rv0946): phospho‐glucose isomerase; Pgk (Rv1437): phosphoglycerate kinase; PpgK (Rv2702): polyphosphate glucokinase; PrpC (Rv1131): methyl‐citrate synthase; PrpD (Rv1130): methyl‐citrate dehydratase; PykA (Rv1617); pyruvate kinase; Sdh1/2 (Rv2047c‐Rv2049c/Rv3316‐3319): succinate dehydrogenase; Tpi (Rv1438): triosephosphate isomerase. GABA: 4‐aminobutyric acid. SSA: succinic semialdehyde. */**/***: see supplementary information.