Table 3.
Clinical signs and pathology reported in offspring of Cache Valley virus‐infected ewes and does across nine observational and eight experimental studies
| Outcomes of CVV infection | Number of studies reporting the sign | |||
|---|---|---|---|---|
| No. of observational studies | Proportion (%) subjects affected | No. of experimental studies | Proportion (%) subjects affected | |
| Clinical signs | ||||
| Appetite loss | 1 | 100.0 | ||
| Depression | 1 | 100.0 | ||
| Disorientation | 1 | NRa | ||
| Dystocia | 1 | NRa | 1 | 5.6 |
| Fever | 2 | NRa | ||
| Muscle spasms | 1 | NRa | ||
| Seizure | 1 | NRa | ||
| Suckling difficulties | 1 | NRa | ||
| Tremors | 1 | NRa | ||
| Congenital defects | ||||
| Ankylosis | 1 | 15.0 | ||
| Ataxia | 1 | NRa | ||
| Arthrogryposis | 5 | 50.0–80.0 | 5 | 12.5–41.6 |
| Concave spinal flexion | 1 | 6.3 | ||
| Encephalopathy | 3 | 93.3–100.0 | 1 | NRa |
| Hydranencephaly | 1 | NRa | 2 | 2.8 |
| Hydrocephalus | 1 | NRa | 1 | NRa |
| Inability to walk | 1 | 5.0 | ||
| Incomplete diaphragm | 1 | NRa | ||
| Kyphosis | 2 | NRa | 2 | 5.6–12.5 |
| Limb stiffness | 1 | NRa | ||
| Micromyelia | 1 | NRa | ||
| Mummification | 2 | NRa | 3 | 11.1–27.8 |
| Muscular abnormalities | 5 | NRa | 1 | NRa |
| Scoliosis | 5 | NRa | 2 | 5.6 |
| Skeletal abnormalities | 3 | 5.0–19.2 | ||
| Low birthweight | 1 | NRa | ||
| Stillbirths | 5 | 5.0–50.0 | ||
| Torticollis | 5 | NRa | 3 | 11.1–12.5 |
| Vertebral malformations | 1 | NRa | 1 | NRa |
| Weak/small trachea | 1 | 5.0 | ||
| Generalized weakness | 1 | 50.0 | ||
a
NR = proportion affected by symptom not reported in one or more articles.