Table 2.

Pharmacokinetic profiles of (R,S)‐ketamine in humans

Route	Dose	Bioavailability	Tmax (min)
Intravenous†	1–4.5 mg/kg	100%	3
Intramuscular†	6.5–13 mg/kg	93%	5–10
Intranasal†	0.5–1.0 mg/kg	8%–45%	10–20
Oral†	0.25–0.5 mg/kg	17%–29%	30
Rectal†	9–10 mg/kg	11%–25%	30–45
Sublingual‡	25 mg	24%–30%	30–45

^† From Li and Vlisides.41

^‡ From Peltoniemi et al.42